Microglia are gatekeepers in the CNS for a wide range of pathological stimuli and they blow
the whistle when things go wrong. Collectively, microglia form a CNS tissue alarm system …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of
temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

This special issue of Experimental Neurology is devoted to the role of Microglia and Chronic
Pain. Chronic pain affects 116 million people per year in the United States, which is more …

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself.
Current treatment options for this condition are often unsatisfactory. From being originally …

Glial cells, composed of microglia, astrocytes, and oligodendrocytes, outnumber neurons in
the central nervous system. The crosstalk between these cells and neurons is now …

Chronic pain is a debilitating condition that often emerges as a clinical symptom of
inflammatory diseases. It has therefore been widely accepted that the immune system …

The role of microglia and their contribution to the development and maintenance of pain
states has emerged as an attractive field of study. Sensitization of central nociceptors and …