The primary objective of this study is to review the efficacy of duloxetine in treating chronic
pain using the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials …

Background Comorbid depression and depressive symptoms are common in patients with
chronic low back pain (CLBP). Duloxetine is clinically effective in major depressive disorder …

Background Major depressive disorder (MDD) is a chronic and highly disabling condition.
Existing pharmacotherapies produce full remission in only 30% to 40% of treated patients …

Background To investigate the association of the change of painful physical symptoms
(PPS) after 4 weeks, with the 6-month treatment outcomes of depressive symptoms in …

In depressed patients tricyclic antidepressants and selective serotonin and noradrenaline
reuptake inhibitors can reduce not only depressive, but also painful physical symptoms. We …

Objective: Debate continues regarding whether onset of analgesia is faster than
antidepressant effect in antidepressants with both properties. Duloxetine hydrochloride (from …

Background The most prominent feature of melancholic depression is a near-total loss of the
capacity to derive pleasure from activities or other positive stimuli. Additional symptoms can …

Background: This study was designed to assess clinical and functional outcomes associated
with switching to duloxetine treatment in patients with major depressive disorder (MDD) …

This randomized, double-blind, placebo-controlled study assessed efficacy and safety of
duloxetine in patients with chronic low back pain (CLBP). Adults (n= 401) with a …

This was a 12-week, randomized, double-blind, placebo-controlled trial to assess the
efficacy and safety of duloxetine, a selective serotonin and norepinephrine reuptake …