[HTML][HTML] PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

[HTML][HTML] Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading

FY Han, KJ Thurecht, AK Whittaker… - Frontiers in …, 2016 - frontiersin.org
Poly (lactic-co-glycolic acid)(PLGA) is the most widely used biomaterial for
microencapsulation and prolonged delivery of therapeutic drugs, proteins and antigens …

Novel approaches in microparticulate PLGA delivery systems encapsulating proteins

A Taluja, YS Youn, YH Bae - Journal of Materials Chemistry, 2007 - pubs.rsc.org
Poly (lactide-co-glycolide)(PLGA) microspheres have been widely investigated as controlled-
release carriers for proteins. Proteins may undergo physical denaturation and chemical …

Poly (lactic-co-glycolic acid) microsphere production based on quality by design: a review

Y Hua, Y Su, H Zhang, N Liu, Z Wang, X Gao, J Gao… - Drug Delivery, 2021 - Taylor & Francis
Poly (lactic-co-glycolic acid)(PLGA) has garnered increasing attention as a candidate drug
delivery polymer owing to its favorable properties, including its excellent biocompatibility …

Microencapsulation of protein drugs for drug delivery: strategy, preparation, and applications

G Ma - Journal of Controlled Release, 2014 - Elsevier
Abstract Bio-degradable poly (lactide)(PLA)/poly (lactide–glycolide)(PLGA) and chitosan
microspheres (or microcapsules) have important applications in Drug Delivery Systems …

Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding

B Wan, Q Bao, D Burgess - Advanced drug delivery reviews, 2023 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) microspheres are a sustained-release drug delivery
system with several successful commercial products used for the treatment of a variety of …

Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres

HB Ravivarapu, K Burton, PP DeLuca - European Journal of Pharmaceutics …, 2000 - Elsevier
The objective of this study was to evaluate the effect of polymer and microsphere blending in
achieving both a sufficient initial release and a desired continuous release of a peptide from …

PLGA micro and nanoparticles in delivery of peptides and proteins; problems and approaches

S Mohammadi-Samani, B Taghipour - Pharmaceutical …, 2015 - Taylor & Francis
During the last decades, many of the poorly controlled diseases were treated using newly
developed peptide and proteins. Although the majority of such therapeutic moieties have …

Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone

Y Capan, G Jiang, S Giovagnoli, KH Na, PP DeLuca - Aaps Pharmscitech, 2003 - Springer
The purpose of this research was to assess the physicochemical properties of a controlled
release formulation of recombinant human growth hormone (rHGH) encapsulated in poly (D …

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Y Su, B Zhang, R Sun, W Liu, Q Zhu, X Zhang… - Drug …, 2021 - Taylor & Francis
Biodegradable microspheres have been widely used in the field of medicine due to their
ability to deliver drug molecules of various properties through multiple pathways and their …