Polymeric drugs based on bioactive glycosides for the treatment of brain tumours

MLL Donaire, J Parra-Cáceres, B Vázquez-Lasa… - Biomaterials, 2009 - Elsevier
Polymeric drugs carrying glycolipids have been designed as target macromolecules for the
treatment of brain tumours. A methacrylate derivative of oleyl 2-acetamido-2-deoxy-α-d …

Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix

A Fernández-Mayoralas, N De La Figuera… - Journal of medicinal …, 2003 - ACS Publications
An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been
synthesized and evaluated as an inhibitor of neural tumor growth. The glycoside inhibited …

Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs

GA Abraham, A Gallardo, J San Román… - … Research Part A: An …, 2003 - Wiley Online Library
Graft copolymers of poly (ϵ‐caprolactone)(PCL) on poly (dimethylacrylamide)(PDMAm),
poly (methylmethacrylate)(PMMA), or on copolymers of poly (DMAm‐co‐MMA) have been …

Glycosylated paclitaxel mixed nanomicelles: Increasing drug brain accumulation and enhancing its in vitro antitumoral activity in glioblastoma cell lines

J Riedel, M Pibuel, E Bernabeu, D Poodts… - Journal of Drug Delivery …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common, most aggressive and lethal of brain
cancers. Patients with GBM exhibit a survival between 12 and 15 months. Unfortunately …

[HTML][HTML] Biocompatible copolymer formulations to treat glioblastoma multiforme

LCS Erthal, OL Gobbo, E Ruiz-Hernandez - Acta biomaterialia, 2021 - Elsevier
The treatment for glioblastoma multiforme (GBM) has not changed for more than 20 years
while the prognosis for the patients is still poor and most of them survive less than 1 year …

[HTML][HTML] The Synthesis and Characterization of a Delivery System Based on Polymersomes and a Xanthone with Inhibitory Activity in Glioblastoma

A Alves, AM Silva, C Nunes, S Cravo, S Reis, M Pinto… - Life, 2024 - mdpi.com
Glioblastoma (GBM) is the most common and deadly primary malignant brain tumor. Current
therapies are insufficient, and survival for individuals diagnosed with GBM is limited to a few …

Thermosensitive injectable fibrillar gels based on cellulose nanocrystals grafted with poly (N-isopropylacrylamide) as biocompatible brain implants

AA Belyaeva, AS Averchuk, NA Rozanova… - Carbohydrate …, 2024 - Elsevier
Drug treatment of glioblastoma, the most aggressive and widespread form of brain cancer, is
complicated due to the difficulty of penetration of chemotherapeutic drugs through the blood …

[HTML][HTML] Structure Activity Relationships of N-linked and Diglycosylated Glucosamine-Based Antitumor Glycerolipids

M Ogunsina, H Pan, P Samadder, G Arthur… - Molecules, 2013 - mdpi.com
1-O-Hexadecyl-2-O-methyl-3-O-(2'-amino-2'-deoxy-β-d-glucopyranosyl)-sn-glycerol (1) was
previously reported to show potent in vitro antitumor activity on a range of cancer cell lines …

[HTML][HTML] Development of polymer-based nanoformulations for glioblastoma brain cancer therapy and diagnosis: An update

B Rabha, KK Bharadwaj, S Pati, BK Choudhury… - Polymers, 2021 - mdpi.com
Brain cancers, mainly high-grade gliomas/glioblastoma, are characterized by uncontrolled
proliferation and recurrence with an extremely poor prognosis. Despite various conventional …

Designing bioresorbable polyester matrices for controlled doxorubicin release in glioma therapy

J Kasperczyk, K Stoklosa, P Dobrzynski… - International journal of …, 2009 - Elsevier
The influence of the chain microstructure on release process of doxorubicin from polymeric
matrices was analyzed. Aliphatic polyester copolymers with optimal chain microstructure, ie …