[HTML][HTML] Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
[HTML][HTML] T-helper cells and their cytokines in pathogenesis and treatment of asthma
T Ji, H Li - Frontiers in Immunology, 2023 - frontiersin.org
Prosperous advances in understanding the cellular and molecular mechanisms of chronic
inflammation and airway remodeling in asthma have been made over the past several …
inflammation and airway remodeling in asthma have been made over the past several …
Emerging roles of T helper subsets in the pathogenesis of asthma
DM Durrant, DW Metzger - Immunological investigations, 2010 - Taylor & Francis
The cardinal features of asthma include pulmonary inflammation and airway
hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been …
hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been …
Modeling TH2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma
In this review, we highlight experiments conducted in our laboratories that have elucidated
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
Transcriptional profiling of Th2 cells identifies pathogenic features associated with asthma
G Seumois, J Zapardiel-Gonzalo, B White… - The Journal of …, 2016 - journals.aai.org
Allergic asthma and rhinitis are two common chronic allergic diseases that affect the lungs
and nose, respectively. Both diseases share clinical and pathological features characteristic …
and nose, respectively. Both diseases share clinical and pathological features characteristic …
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …
Functions of T cells in asthma: more than just TH2 cells
Asthma has been considered a T helper 2 (TH2) cell-associated inflammatory disease, and
TH2-type cytokines, such as interleukin-4 (IL-4), IL-5 and IL-13, are thought to drive the …
TH2-type cytokines, such as interleukin-4 (IL-4), IL-5 and IL-13, are thought to drive the …
The role of the T cell in asthma
DS Robinson - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
Since the initial detection of TH2 cytokines in asthmatic airways, our understanding of the
complexity of T-cell subtypes and flexibility and of the potential role of airway structural cells …
complexity of T-cell subtypes and flexibility and of the potential role of airway structural cells …
Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease
RA Rahimi, K Nepal, M Cetinbas, RI Sadreyev… - Journal of Experimental …, 2020 - rupress.org
Memory CD4+ T helper type 2 (Th2) cells drive allergic asthma, yet the mechanisms
whereby tissue-resident memory Th2 (Th2 Trm) cells and circulating memory Th2 cells …
whereby tissue-resident memory Th2 (Th2 Trm) cells and circulating memory Th2 cells …