To the Editor: Recently, Fricker et al 1 reported that an expression signature in the sputum
efficiently predicted exacerbations among patients with asthma, showing the greatest …

To the Editor: Asthma affects approximately 7 million children in the United States, where
approximately 11% to 13% of children report respiratory or skin allergies. Genetic variants …

To the Editor: Inhaled corticosteroids (ICS) are the primary antiinflammatory therapy for the
control and management of asthma, but their effects are characterized by some inter …

To the Editor: Allergic asthma is a multifactorial disorder in which activation and
differentiation of B lymphocytes toward the production of IgE play an essential role. In these …

LETTERS TO THE EDITOR 575 between the chromosome 11 open reading frame 30
(C11orf30) and leucine-rich repeat containing 32 (LRRC32) genes. 1 A replication study …

To the Editor: The cytokine IL-6 can participate in asthma pathogenesis, 1 and it is produced
as a response to different stimuli, including tobacco smoke. 2 Recently, we reported an …

To the Editor: Gene-environment interactions are thought to play a critical role in determining
asthma incidence and severity. A human IL-4 receptor alpha chain gene (IL4R) variant that …

''La'ci darem la mano''—''There we'll be hand in hand''—sings Don Giovanni to Zerlina in Act
1 of the opera the Danish philosopher Søren Kierkegaard called ''a work without blemish, of …

To the Editor: The susceptibility of individuals to developing asthma is the result of a
complex interplay between genetics and environmental trigger factors. The advent of high …

To the Editor: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin
diseases and is associated with other atopic diseases such as asthma, allergic rhinitis, and …