Although it is well known that DNA methylation serves to repress gene expression, precisely
how it functions during the process of development remains unclear. Here, we propose that …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

From a fertilised egg to a mature organism, cells divide and accumulate epigenetic
information, which is faithfully passed on to daughter cells. DNA methylation consolidates …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …