Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

The phosphoinositide 3-kinase (PI3K) pathway is activated in a variety of different human
cancers, and inhibitors of this pathway are under active development as anti-cancer …

Abstract Phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway plays a crucial role in integrating a variety of extracellular stimuli to regulate growth …

PI3K-AKT-mTOR and Ras-Raf-MEK-ERK are the most commonly altered oncogenic
pathways in solid malignancies. There has been a lot of enthusiasm to develop inhibitors to …

Introduction: The RAS/RAF/MAP kinase–ERK kinase (MEK)/extracellular-signal-regulated
kinase (ERK)(MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR)(PI3K) …

Abstract The PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways are two of the most
frequently dysregulated kinase cascades in human cancer. Molecular alterations in these …

Aberrations in various cellular signaling pathways are instrumental in regulating cellular
metabolism, tumor development, growth, proliferation, metastasis and cytoskeletal …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …