Although there is growing interest in the use of brain tissue oxygenation as a resuscitative
endpoint, many of these therapies are based on physiologic principles with little robust …

Objectives: A relationship between reduced brain tissue oxygenation and poor outcome
following severe traumatic brain injury has been reported in observational studies. We …

Abstract Background Brain tissue oxygen (PbtO 2) monitoring is used in severe traumatic
brain injury (TBI) patients. How brain reduced PbtO 2 should be treated and its response to …

Cerebral ischemia is a well-recognized contributor to high morbidity and mortality after
traumatic brain injury (TBI). Standard of care treatment aims to maintain a sufficient oxygen …

Cerebral oxygenation represents the balance between oxygen delivery, consumption and
utilization by the brain, and therefore reflects the adequacy of cerebral perfusion. Different …

The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …

To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential.
Cerebral tissue oxygenation represents the balance between oxygen supply and …

Insults to the brain from trauma or subarachnoid hemorrhage (SAH) produce changes in
structure, pressure dynamics, chemical balance, and blood flow. Ultimately, the delivery of …

Shock is a systemic form of acute circulatory failure leading to cellular dysoxia and death.
Such a state of aerobic metabolism failure also underlies neuronal cell death in severe …

Background In patients with severe traumatic brain injury (TBI), the depth and duration of
cerebral hypoxia are independent predictors of outcome. This study aimed to evaluate the …