Novel therapeutic strategies for renal graft preservation and their potential impact on the future of clinical transplantation

S Juriasingani, M Akbari, P Luke… - Current Opinion in Organ …, 2019 - journals.lww.com
Progress has been made in investigating improvements and alternatives to cold
preservation. Promising therapeutic strategies have also been studied in the context of cold …

I: negative effect of cold ischemia on initial renal function

BM Stubenitsky, MH Booster, L Brasile, EM Green… - ASAIO …, 2000 - journals.lww.com
Correlation between post-transplant function and exposure to cold ischemia (CI) during
preservation has been reported. We attempted to identify the effect of CI on renal function …

Minimising cold ischaemic injury in an experimental model of kidney transplantation

SA Hosgood, A Bagul… - European journal of …, 2011 - Wiley Online Library
Eur J Clin Invest 2011; 41 (3): 233–240 Abstract Background Cold ischaemic (CI) injury is
associated with reduced renal graft function and survival. However, there is little evidence …

[HTML][HTML] Preservation solutions for static cold storage of kidney allografts: a systematic review and meta-analysis

JM O'Callaghan, SR Knight, RD Morgan… - American Journal of …, 2012 - Elsevier
Static cold storage is the most prevalent method for renal allograft preservation. Several
solutions have been designed to counteract the detrimental effects of cold ischemia and …

Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts

T Minor, C von Horn, A Paul - Current Opinion in Organ …, 2017 - journals.lww.com
Machine perfusion after conventional cold storage is beneficial for ulterior function after
transplantation. Cold grafts should be initially perfused at low temperatures allowing for …

[HTML][HTML] Current evidence and future perspectives to implement continuous and end-ischemic use of normothermic and oxygenated hypothermic machine perfusion in …

M Foguenne, S MacMillan, P Kron, J Nath… - Journal of clinical …, 2023 - mdpi.com
The use of high-risk renal grafts for transplantation requires the optimization of pretransplant
assessment and preservation reconditioning strategies to decrease the organ discard rate …

A pilot study assessing the feasibility of a short period of normothermic preservation in an experimental model of non heart beating donor kidneys

SA Hosgood, AD Barlow, PJ Yates, MGJ Snoeijs… - Journal of Surgical …, 2011 - Elsevier
BACKGROUND: Restoring metabolism to an organ after hypothermic storage and before
transplantation could reverse some of the detrimental effects of ischemic injury. This may be …

Therapeutic hypothermia in organ donors: follow-up and safety analysis

D Malinoski, MS Patel, DA Axelrod, K Broglio… - …, 2019 - journals.lww.com
Background. In a recent trial, targeted mild hypothermia in brain-dead organ donors
significantly reduced the incidence of delayed graft function after kidney transplantation. This …

Consequences of cold ischemic injury of kidneys in clinical transplantation

AK Salahudeen - 2004 - journals.sagepub.com
Cold storage allows the effective utilization of organs retrieved for transplantation. However,
prolonged cold ischemia contributes to organ damage and increases patients' morbidity and …

[HTML][HTML] Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation

N Abraham, Q Gao, R Kahan, IS Alderete… - Transplantation …, 2024 - journals.lww.com
Background. Ex vivo kidney perfusion is an evolving platform that demonstrates promise in
preserving and rehabilitating the kidney grafts. Despite this, there is little consensus on the …