Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of
temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself.
Current treatment options for this condition are often unsatisfactory. From being originally …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Microglial cells are specialized macrophage cells of the central nervous system responsible
for the innate immunity of the spinal cord and the brain. They protect the brain and spinal …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Chronic pain is a debilitating condition that often emerges as a clinical symptom of
inflammatory diseases. It has therefore been widely accepted that the immune system …