Genetic predisposition in type 2 diabetes: a promising approach toward a personalized management of diabetes

MM Sirdah, NS Reading - Clinical Genetics, 2020 - Wiley Online Library
Diabetes mellitus, also known simply as diabetes, has been described as a chronic and
complex endocrine metabolic disorder that is a leading cause of death across the globe. It is …

Insights into type 1 diabetes provided by genetic analyses

G Morahan - Current Opinion in Endocrinology, Diabetes and …, 2012 - journals.lww.com
Insights into type 1 diabetes provided by genetic analyses : Current Opinion in Endocrinology,
Diabetes and Obesity Insights into type 1 diabetes provided by genetic analyses : Current …

The genetics of type 2 diabetes and its clinical relevance

A Pal, MI McCarthy - Clinical genetics, 2013 - Wiley Online Library
The increasing worldwide prevalence of type 2 diabetes (T2D) motivates efforts to use
genetics to define key pathways involved in disease predisposition, and thereby to improve …

[PDF][PDF] Rare and common genetic events in type 2 diabetes: what should biologists know?

A Bonnefond, P Froguel - Cell metabolism, 2015 - cell.com
Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …

The genetic side of type 2 diabetes–a review

S Cuschieri - Diabetes & Metabolic Syndrome: Clinical Research & …, 2019 - Elsevier
Abstract Aim Type 2 diabetes (T2DM) is a complex disease. Interactions between genetic
susceptible variants and environmental cues results in the development of this …

Genetics of type 2 diabetes

E Ahlqvist, TS Ahluwalia, L Groop - Clinical chemistry, 2011 - academic.oup.com
BACKGROUND Type 2 diabetes (T2D) is a complex disorder that is affected by multiple
genetic and environmental factors. Extensive efforts have been made to identify the disease …

[HTML][HTML] Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application

X Sun, W Yu, C Hu - BioMed research international, 2014 - ncbi.nlm.nih.gov
With rapidly increasing prevalence, diabetes has become one of the major causes of
mortality worldwide. According to the latest studies, genetic information makes substantial …

[HTML][HTML] Type 2 diabetes genetics: beyond GWAS

DK Sanghera, PR Blackett - Journal of diabetes & metabolism, 2012 - ncbi.nlm.nih.gov
The global epidemic of type 2 diabetes mellitus (T2D) is one of the most challenging
problems of the 21 st century leading cause of and the fifth death worldwide. Substantial …

The genetic epidemiology of type 2 diabetes: opportunities for health translation

JB Meigs - Current diabetes reports, 2019 - Springer
Abstract Purpose of Review Genome-wide association studies have delineated the genetic
architecture of type 2 diabetes. While functional studies to identify target transcripts are …

Genetics of type 2 diabetes and clinical utility

R Dorajoo, J Liu, BO Boehm - Genes, 2015 - mdpi.com
A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent
genetics. Recent genetic studies, especially genome-wide association studies (GWAS) …