PCSK9 inhibition in clinical practice: treatment patterns and attainment of lipid goals in a large health maintenance organization

B Zafrir, A Egbaria, N Stein, A Elis, W Saliba - Journal of Clinical Lipidology, 2021 - Elsevier
Background Proprotein convertase subtilisin/kexin type-9 inhibitors (PCSK9i) effectively
reduce low-density lipoprotein cholesterol (LDL-C), improving cardiovascular outcomes in …

Safety, adherence and efficacy of PCSK9 inhibitors: a retrospective real-world study

BLK Chng, WMP Heng, YM Soon… - Proceedings of …, 2022 - journals.sagepub.com
Introduction PCSK9 inhibitors demonstrated their effectiveness in reducing low-density
lipoprotein cholesterol (LDL-C) and cardiovascular events in landmark trials. It remains …

Application of PCSK9 inhibitors in practice: part 2: the patient experience

TM Kaufman, BA Warden, J Minnier, JR Miles… - Circulation …, 2019 - Am Heart Assoc
PCSK9i (protein convertase subtilisin/kexin type 9 inhibitors) are set to revolutionize the
treatment of hypercholesterolemia in the management of atherosclerotic risk, but numerous …

Use of Low‐Density Lipoprotein–Lowering Therapies Before and After PCSK9 Inhibitor Initiation

JA Rymer, KE Mues, KL Monda… - Journal of the …, 2020 - Am Heart Assoc
Background Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK 9i) are used to
reduce low‐density lipoprotein (LDL) cholesterol. PCSK 9i use after initiation, as well as …

[HTML][HTML] PCSK9 inhibitors in clinical practice: delivering on the promise?

RM Stoekenbroek, ML Hartgers, R Rutte, DD de Wijer… - Atherosclerosis, 2018 - Elsevier
Background and aims In clinical trials, protein convertase subtilisin/kexin type 9 (PCSK9)
inhibitors robustly lowered LDL-cholesterol (LDL-c) and had a favorable tolerability and …

Exploring rates of PCSK9 inhibitor persistence and reasons for treatment non-persistence in an integrated specialty pharmacy model

DR Donald, VW Reynolds, N Hall, J DeClercq… - Journal of Clinical …, 2022 - Elsevier
Background Nearly 40% of patients do not continue proprotein convertase subtilisin/kexin
type 9 inhibitor (PCSK9i) therapy after 6 months, despite their ability to lower low-density …

[HTML][HTML] PCSK9 inhibitors revisited: effectiveness and safety of PCSK9 inhibitors in a real-life Spanish cohort

J Vicente-Valor, X García-González… - Biomedicine & …, 2022 - Elsevier
Introduction Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have emerged
as a therapeutic option for patients with hypercholesterolemia who do not attain low-density …

Effectiveness, safety, and adherence to treatment of proprotein convertase subtilisin/Kexin Type 9 inhibitors in real practice

M Gayoso-Rey, O Díaz-Trastoy, EY Romero-Ventosa… - Clinical Therapeutics, 2021 - Elsevier
Purpose To evaluate the effectiveness, adverse reactions, and adherence to treatment of
hypolipidemic inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9is) in a …

PCSK9 inhibitors in a German single-center clinical practice: real-world treatment of patients at high cardiovascular risk over 68 weeks

T Hollstein, U Kassner, T Grenkowitz… - American Journal of …, 2021 - Springer
Aims Several the use of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) for
patients at high/very high cardiovascular risk who are inadequately treated with maximally …

Lipid-lowering therapy with PCSK9-inhibitors in the management of cardiovascular high-risk patients: effectiveness, therapy adherence and safety in a real world …

M Saborowski, M Dölle, MP Manns, H Leitolf… - Cardiology …, 2018 - journals.viamedica.pl
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9)-inhibitors have shown
great potential in efficient lipid lowering to achieve low-density lipoprotein-cholesterol (LDL …