This dissertation consists of a series of studies targeting significant gaps in our
understanding of reflex tracheobronchial cough. The first study demonstrates that the cough …

The role of the cerebellum in controlling the cough motor pattern is not well understood. We
hypothesized that cerebellectomy would disinhibit motor drive to respiratory muscles during …

We tested the hypothesis, motivated in part by a coordinated computational cough network
model, that alterations of mean systemic arterial blood pressure (BP) influence the …

Recurrent laryngeal afferent fibers are primarily responsible for cough in response to
mechanical or chemical stimulation of the upper trachea and larynx in the guinea pig. Lower …

63 This study is the first to explore the role of the inspiratory rhythm and pattern generator,
the 64 pre-Bötzinger complex (PreBötC), in cough motor pattern formation. In the PreBötC …

We have previously described the physiological and morphological properties of the cough
receptors and their sites of termination in the airways and centrally in the nucleus tractus …

Enhanced coughing can be produced in a variety of animal models, including the guinea
pig, cat, dog and pig. Typically, airway inflammation has been produced by sensitization …

The cough reflex is one of several defensive reflexes that serve to protect the airways from
the potentially damaging effects of inhaled particulate matter, aeroallergens, pathogens …

Recent studies evaluating the effects of pulmonary afferents, chemoreceptors, and
antitussive drugs on the cough motor pattern indicate that this reflex is regulated in a …

The c-fos gene expression method was used to localize brainstem neurons functionally
related to the tracheal–bronchial cough on 13 spontaneously breathing, pentobarbitone …