Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

CK2 is a multitask kinase whose role is essential for a countless number of cellular
processes, many of which are critical for blood cell development. A prevailing task for this …

At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

CK2 is probably the most pleiotropic Ser/Thr protein kinase with hundreds of endogenous
substrates already known, which are implicated in a variety of cellular functions. At variance …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Protein kinase CK2 (formerly referred to as casein kinase II) is an evolutionary conserved,
ubiquitous protein kinase. There are two paralog catalytic subunits, ie alpha (A1) and …

Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

Protein kinase CK2 is a ubiquitous protein kinase responsible for the phosphorylation of Ser
and Thr residues specified by acidic side chains in many proteins, including several key …

Protein kinase CK2 appears to interact with different signaling pathways and therefore
represents the prototype of a multifunctional protein kinase. The enzyme is highly expressed …