Pseudomonas aeruginosa Population Diversity and Turnover in Cystic Fibrosis Chronic Infections

E Mowat, S Paterson, JL Fothergill… - American journal of …, 2011 - atsjournals.org
Rationale: Pseudomonas aeruginosa isolates from chronic cystic fibrosis lung infections
display multiple phenotypes indicating extensive population diversity. Objectives: We aimed …

[HTML][HTML] Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis

A Ashish, S Paterson, E Mowat, JL Fothergill… - Journal of Cystic …, 2013 - Elsevier
Abstract Background Populations of the Liverpool Epidemic Strain (LES) of Pseudomonas
aeruginosa undergo extensive diversification in the cystic fibrosis (CF) lung during long-term …

Divergent, Coexisting Pseudomonas aeruginosa Lineages in Chronic Cystic Fibrosis Lung Infections

D Williams, B Evans, S Haldenby… - American journal of …, 2015 - atsjournals.org
Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections of
patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within …

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis

ST Clark, J Diaz Caballero, M Cheang, B Coburn… - Scientific reports, 2015 - nature.com
Chronic airway infections caused by Pseudomonas aeruginosa contribute to the
progression of pulmonary disease in individuals with cystic fibrosis (CF). In the setting of CF …

Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient

ML Workentine, CD Sibley, B Glezerson, S Purighalla… - PloS one, 2013 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways
of patients with cystic fibrosis. Throughout the course of infection this organism undergoes …

Shared Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres

TJ Kidd, KA Ramsay, H Hu, GB Marks… - European …, 2013 - Eur Respiratory Soc
Recent molecular-typing studies suggest cross-infection as one of the potential acquisition
pathways for Pseudomonas aeruginosa in patients with cystic fibrosis (CF). In Australia …

Genomic variation among contemporary Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients

JCS Chung, J Becq, L Fraser… - Journal of …, 2012 - Am Soc Microbiol
The airways of individuals with cystic fibrosis (CF) often become chronically infected with
unique strains of the opportunistic pathogen Pseudomonas aeruginosa. Several lines of …

Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection

SE Darch, A McNally, F Harrison, J Corander… - Scientific reports, 2015 - nature.com
Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …

Fluctuations in phenotypes and genotypes within populations of Pseudomonasaeruginosa in the cystic fibrosis lung during pulmonary exacerbations

JL Fothergill, E Mowat, MJ Ledson… - Journal of medical …, 2010 - microbiologyresearch.org
Chronic respiratory infection by Pseudomonas aeruginosa contributessignificantly to the
morbidity and mortality associated with cystic fibrosis (CF). Using a series of phenotypic and …

Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections

C Winstanley, S O'Brien, MA Brockhurst - Trends in microbiology, 2016 - cell.com
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …