Overfeeding of a hypercaloric diet leads to obesity, diabetes, chronic inflammation, and fatty
liver disease. Although limiting fat or carbohydrate intake is the cornerstone for obesity …

Background: Obesity is a chronic progressive disease with several metabolic alterations.
Nonalcoholic fatty liver disease (NAFLD) is an important comorbidity of obesity that can …

Objective Obesity and metabolic complications, such as type 2 diabetes and nonalcoholic
fatty liver disease (NAFLD), are one of the greatest public health challenges of the 21st …

Background Obesity and inflammation are highly integrated processes in the pathogenesis
of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular …

Overnutrition and obesity have developed into a major public health problem across
different parts of the world. Epidemiological studies have shown that excessive intake of …

Introduction: The biggest risk factor for obesity and its associated comorbidities is a Western
diet. This Western diet induces adipose tissue (AT) inflammation, which causes an AT …

Long-term adherence to a high-fat, high-calorie diet influences human health and causes
obesity, metabolic syndrome and nonalcoholic steatohepatitis (NASH). Inflammation plays a …

It is still unclear if an isoenergetic, sucrose-rich diet leads to health consequences. Aims To
investigate the effects of excessive sucrose within an isoenergetic diet on metabolic …

Background & Aims The factors that distinguish metabolically healthy obesity from
metabolically unhealthy obesity are not well understood. Diet has been implicated as a …

Purpose To perform a large-scale gene profiling of the liver in a mouse model of fatty liver
induced by high carbohydrate (sucrose) diet (HCD) to gain a deeper insight into potential …