Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in
gene regulation,,–. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation …

Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event
that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby …

The Rpd3S histone deacetylase complex represses cryptic transcription initiation within
coding regions by maintaining the hypo‐acetylated state of transcribed chromatin. Rpd3S …

Nucleosomes must be deacetylated behind elongating RNA polymerase II to prevent cryptic
initiation of transcription within the coding region. RNA polymerase II signals for …

In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

The Rpd3S histone deacetylase complex utilizes two subunits, Eaf3 and Rco1, to recognize
nucleosomes methylated at H3K36 (H3K36me) with high affinity and strong specificity …

Deacetylation of nucleosomes by the Rpd3S histone deacetylase along the path of
transcribing RNA polymerase II regulates access to DNA, contributing to faithful gene …

Chromatin remodelers have been implicated in the regulation of histone-modifying
complexes. However, the underlying mechanism remains poorly understood. The Rpd3S …

Histone methylation is associated with both transcription activation and repression.
However, the functions of different states of methylation remain largely elusive. Here, using …

We describe the genome-wide distribution of the histone deacetylase and repressor Rpd3
and its associated proteins Ume1 and Ume6 in Saccharomyces cerevisiae. Using a new …