Six1 is a member of the six-homeodomain family of transcription factors. Six1 is expressed in
multiple embryonic cell types and plays important roles in proliferation, differentiation and …

In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

Background Lung cancer is a common cancer and the leading cause of cancer-related
death worldwide. SIX3 is a human homologue of the highly conserved sine oculis gene …

The Six1 homeobox gene plays critical roles in vertebrate organogenesis. Mice deficient for
Six1 show severe defects in organs such as skeletal muscle, kidney, thymus, sensory …

A number of homeobox genes are implicated in the malignancy of various cancers. Here, we
investigated the role of the homeobox gene SIX4 in non-small-cell lung cancer (NSCLC) …

Homeoproteins are transcription factors that act as master regulators of development and
are frequently dysregulated in cancers. During embryogenesis, the Six1 homeoprotein is …

Six genes are widely expressed during vertebrate embryogenesis, suggesting that they are
implicated in diverse differentiation processes. To determine the functions of the Six1 gene …

Objectives The roles and related mechanisms of six2 in regulating non–small cell lung
cancer (NSCLC) cells progression are unclear. This work aimed to explore the roles of six2 …

Six1, a member of the Six family of homeodomain transcription factors, is overexpressed in
various human cancers, and SIX1 overexpression is associated with tumor progression and …

Jaw morphogenesis is a complex event mediated by inductive signals that establish and
maintain the distinct developmental domains required for formation of hinged jaws, the …