From organic and inorganic phosphates to valvular and vascular calcifications

M Bäck, JB Michel - Cardiovascular Research, 2021 - academic.oup.com
Calcification of the arterial wall and valves is an important part of the pathophysiological
process of peripheral and coronary atherosclerosis, aortic stenosis, ageing, diabetes, and …

Vascular calcification: key roles of phosphate and pyrophosphate

R Villa-Bellosta - International Journal of Molecular Sciences, 2021 - mdpi.com
Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are
the leading cause of morbimortality in Western society. Both pathologies are frequently …

New insights into endogenous mechanisms of protection against arterial calcification

R Villa-Bellosta - Atherosclerosis, 2020 - Elsevier
Cardiovascular complications due to accelerated atherosclerosis and arterial stiffening are
the leading cause of morbidity and mortality in the Western society. Both pathologies are …

The biology of vascular calcification

D Quaglino, F Boraldi, FD Lofaro - … review of cell and molecular biology, 2020 - Elsevier
Vascular calcification (VC), characterized by different mineral deposits (ie, carbonate apatite,
whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a …

Tissue non-specific alkaline phosphatase and vascular calcification: a potential therapeutic target

D Azpiazu, S Gonzalo… - Current cardiology …, 2019 - ingentaconnect.com
Vascular calcification is a pathologic phenomenon consisting of calcium phosphate crystal
deposition in the vascular walls. Vascular calcification has been found to be a risk factor for …

Regulation of vascular calcification: roles of phosphate and osteopontin

CM Giachelli, MY Speer, X Li, RM Rajachar… - Circulation …, 2005 - Am Heart Assoc
Vascular calcification is prevalent in aging as well as a number of pathological conditions,
and it is now recognized as a strong predictor of cardiovascular events in the general …

[HTML][HTML] Novel insights into vascular calcification

M Ketteler, C Giachelli - Kidney International, 2006 - Elsevier
Vascular calcification is not just a hallmark of uremic arterio-and atherosclerosis, but also a
significant cardiovascular risk factor in patients with chronic kidney disease. In contrast to the …

Synthesis of extracellular pyrophosphate increases in vascular smooth muscle cells during phosphate-induced calcification

R Villa-Bellosta - Arteriosclerosis, thrombosis, and vascular biology, 2018 - Am Heart Assoc
Objective—Hydroxyapatite deposition on the medial layer of the aortic walls is the hallmark
of vascular calcification and the most common complication in aging individuals and in …

Phosphate and cardiovascular disease beyond chronic kidney disease and vascular calcification

S Disthabanchong - International journal of nephrology, 2018 - Wiley Online Library
Phosphate is essential for life but its accumulation can be detrimental. In end‐stage renal
disease, widespread vascular calcification occurs as a result of chronic phosphate load. The …

[HTML][HTML] Pyrophosphate deficiency in vascular calcification

R Villa-Bellosta, WC O'Neill - Kidney international, 2018 - Elsevier
Pathologic cardiovascular calcification is associated with a number of conditions and is a
common complication of chronic kidney disease. Because ambient calcium and phosphate …