State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease

EA Hoffman, BA Simon, G McLennan - Proceedings of the American …, 2006 - atsjournals.org
With advances in multidetector-row computed tomography (MDCT), it is now possible to
image the lung in 10 s or less and accurately extract the lungs, lobes, and airway tree to the …

Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory …

G Vande Velde, J Poelmans… - Disease models & …, 2016 - journals.biologists.com
In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in
pulmonary research because it provides longitudinal information on dynamic disease …

Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement

S Dubsky, SB Hooper, KKW Siu… - Journal of The Royal …, 2012 - royalsocietypublishing.org
During breathing, lung inflation is a dynamic process involving a balance of mechanical
factors, including trans-pulmonary pressure gradients, tissue compliance and airway …

Quantification of dual-energy CT-derived functional parameters as potential imaging markers for progression of idiopathic pulmonary fibrosis

SC Scharm, J Vogel-Claussen, C Schaefer-Prokop… - European …, 2021 - Springer
Objectives The individual course of disease in idiopathic pulmonary fibrosis (IPF) is highly
variable. Assessment of disease activity and prospective estimation of disease progression …

Functional imaging of the lungs with gas agents

SJ Kruger, SK Nagle, MJ Couch, Y Ohno… - Journal of Magnetic …, 2016 - Wiley Online Library
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

Measuring lung function in airways diseases: current and emerging techniques

N Petousi, NP Talbot, I Pavord, PA Robbins - Thorax, 2019 - thorax.bmj.com
Chronic airways diseases, including asthma, COPD and cystic fibrosis, cause significant
morbidity and mortality and are associated with high healthcare expenditure, in the UK and …

Imaging for lung physiology: what do we wish we could measure?

HT Robertson, RB Buxton - Journal of applied physiology, 2012 - journals.physiology.org
The role of imaging as a tool for investigating lung physiology is growing at an accelerating
pace. Looking forward, we wished to identify unresolved issues in lung physiology that might …

Parametric response mapping monitors temporal changes on lung CT scans in the subpopulations and intermediate outcome measures in COPD Study (SPIROMICS)

JL Boes, BA Hoff, M Bule, TD Johnson, A Rehemtulla… - Academic radiology, 2015 - Elsevier
Rationale and Objectives The longitudinal relationship between regional air trapping and
emphysema remains unexplored. We have sought to demonstrate the utility of parametric …

2D ultrashort echo‐time functional lung imaging

A Balasch, P Metze, K Stumpf, M Beer… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Imaging of the lung by MRI is challenging due to the intrinsic low proton density
and rapid T2* relaxation. MRI methods providing lung parenchyma and function are in …

Quantification of lung function on CT images based on pulmonary radiomic filtering

Z Yang, KJ Lafata, X Chen, J Bowsher… - Medical …, 2022 - Wiley Online Library
Purpose To develop a radiomics filtering technique for characterizing spatial‐encoded
regional pulmonary ventilation information on lung computed tomography (CT). Methods …