Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes
SA Beddows, SR Page, AH Taylor, R McNerney… - Biochemical …, 1989 - Elsevier
Since recent in vivo evidence suggests that the benzofuran antiarrhythmic drug amiodarone
has a direct toxic effect on the human thyroid gland, we have investigated the effects of both …
has a direct toxic effect on the human thyroid gland, we have investigated the effects of both …
Studies on the in vitro cytotoxic effect of amiodarone
L Chiovato, E Martino, M Tonacchera, F Santini… - …, 1994 - academic.oup.com
Amiodarone, a potent antiarrhythmic drug, contains 37.2% iodine by weight and may induce
either hypo-or hyperthyroidism. The high iodine content of amiodarone may be responsible …
either hypo-or hyperthyroidism. The high iodine content of amiodarone may be responsible …
Amiodarone and the thyroid.
RL Kennedy, H Griffiths, TA Gray - Clinical chemistry, 1989 - academic.oup.com
An antiarrhythmic drug, amiodarone, contains 37% iodine by weight and is structurally
similar to the thyroid hormones. The drug inhibits hepatic 5'-deiodinase, resulting in …
similar to the thyroid hormones. The drug inhibits hepatic 5'-deiodinase, resulting in …
The various effects of amiodarone on thyroid function
F Bogazzi, L Bartalena, M Gasperi, LE Braverman… - Thyroid, 2001 - liebertpub.com
Amiodarone, a benzofuranic-derivative iodine-rich drug used mostly for tachyarrhythmias,
often causes changes in the peripheral metabolism of thyroid hormones mainly due to the …
often causes changes in the peripheral metabolism of thyroid hormones mainly due to the …
Amiodarone and thyroid hormone metabolism.
WM Wiersinga, MD Trip - Postgraduate Medical Journal, 1986 - ncbi.nlm.nih.gov
Amiodarone, an antiarrhythmic and anti-anginal agent, contains 75mg oforganic iodine per
200mg active substance. The drug is deiodinated during its biotransformation, and it is …
200mg active substance. The drug is deiodinated during its biotransformation, and it is …
The effects of amiodarone on thyroid hormone function: a review of the physiology and clinical manifestations
HL Figge, J Figge - The Journal of Clinical Pharmacology, 1990 - Wiley Online Library
Amiodarone, an iodinated benzofuran derivative, is used for treatment of refractory cardiac
arrhythmias. Certain features of the drug's structure resemble those of the biologically active …
arrhythmias. Certain features of the drug's structure resemble those of the biologically active …
Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues
JF Brien, S Jimmo, FJ Brennan, SE Ford… - Canadian journal of …, 1987 - cdnsciencepub.com
The distribution of the antiarrhythmic drug amiodarone and its principal lipophilic metabolite,
desethylamiodarone, was determined in postmortem tissues of six patients who received …
desethylamiodarone, was determined in postmortem tissues of six patients who received …
Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy.
PC Adams, DW Holt, GC Storey, AR Morley… - Circulation, 1985 - Am Heart Assoc
The pharmacokinetic characteristics of amiodarone suggest extensive tissue deposition. We
confirmed this by measuring tissue concentrations of the drug and of its major metabolite …
confirmed this by measuring tissue concentrations of the drug and of its major metabolite …
[引用][C] Amiodarone and the thyroid: pharmacological, toxic and therapeutic effects
J Unger, M Lambert, MH Jonckheer… - Journal of internal …, 1993 - Wiley Online Library
Amiodarone has been reported as an anti-anginal drug in 19h7 [11 and as an anti-
arrhythmic drug in 1969 [2]. Thyroid side-effects (hypothyroidism and thyrotoxicosis) were …
arrhythmic drug in 1969 [2]. Thyroid side-effects (hypothyroidism and thyrotoxicosis) were …
[PDF][PDF] Tissue uptake and metabolism of amiodarone after chronic administration in rabbits.
R Kannan, S Miller, BN Singh - Drug metabolism and disposition, 1985 - Citeseer
This study was designed to determine serum and tissue concentra-tions of amiodarone and
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …