Since recent in vivo evidence suggests that the benzofuran antiarrhythmic drug amiodarone
has a direct toxic effect on the human thyroid gland, we have investigated the effects of both …

Amiodarone, a potent antiarrhythmic drug, contains 37.2% iodine by weight and may induce
either hypo-or hyperthyroidism. The high iodine content of amiodarone may be responsible …

An antiarrhythmic drug, amiodarone, contains 37% iodine by weight and is structurally
similar to the thyroid hormones. The drug inhibits hepatic 5'-deiodinase, resulting in …

Amiodarone, a benzofuranic-derivative iodine-rich drug used mostly for tachyarrhythmias,
often causes changes in the peripheral metabolism of thyroid hormones mainly due to the …

Amiodarone, an antiarrhythmic and anti-anginal agent, contains 75mg oforganic iodine per
200mg active substance. The drug is deiodinated during its biotransformation, and it is …

Amiodarone, an iodinated benzofuran derivative, is used for treatment of refractory cardiac
arrhythmias. Certain features of the drug's structure resemble those of the biologically active …

The distribution of the antiarrhythmic drug amiodarone and its principal lipophilic metabolite,
desethylamiodarone, was determined in postmortem tissues of six patients who received …

The pharmacokinetic characteristics of amiodarone suggest extensive tissue deposition. We
confirmed this by measuring tissue concentrations of the drug and of its major metabolite …

Amiodarone has been reported as an anti-anginal drug in 19h7 [11 and as an anti-
arrhythmic drug in 1969 [2]. Thyroid side-effects (hypothyroidism and thyrotoxicosis) were …

This study was designed to determine serum and tissue concentra-tions of amiodarone and
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …