Discoveries of new human viruses and new technologies for their detection have made, and
will continue to make, major contributions to the safety of blood transfusion. This article …

The South American continent presents a great diversity of biomes, whose ecosystems are
constantly threatened by the expansion of human activity. The emergence and re …

Since the early times, human beings have always been faced with deadly microbial
infections, both bacterial and viral. Pathogens such as viruses are always evolving owing to …

Modern laboratory techniques for the detection of novel human viruses are greatly needed
as physicians and epidemiologists increasingly deal with infectious diseases caused by new …

Clinical metagenomics is a broad-range agnostic detection method of pathogens, including
novel microorganisms. A major limit is the low pathogen load compared to the high …

Viral enrichment by probe hybridization has been reported to significantly increase the
sensitivity of viral metagenomics. This study compares the analytical performance of two …

Widespread in public databases, foreign contaminant sequences pose a substantial
obstacle in genomic analyses. Such contamination in viral genome databases is also …

Background New and emerging transfusion–transmitted infections remain a threat to the
blood supply. Blood donors are currently screened for less than half of known agents …

The target-independent identification of viral pathogens using 'shotgun'metagenomic
sequencing is an emerging approach with potentially wide applications in clinical …

This Frontiers in Virology Research Topic showcases how metagenomic and bioinformatic
approaches have been combined to discover, classify and characterize novel viruses. Since …