Osteoarthritis (OA) is common and affected by several factors, such as age, weight, sex, and
genetics. The pathogenesis of OA remains unclear. Therefore, using a rat model of …

Osteoporosis is a common form of metabolic bone disease that is costly to treat and is
primarily diagnosed on the basis of bone mineral density. As the influences of genetic …

Osteoporosis is a complex multifactorial condition of the musculoskeletal system.
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Background: Osteoporosis is a common degenerative bone disease which is characterized
with decreased bone strength and increased risk of fracture. The abnormal bone metabolism …

Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …

Purpose: A key factor in regulating bone absorption is the proportion of RANKL/OPG.
Although many reports showing diverse transcription factors or epigenetic modification could …

Age-related bone loss in humans is associated with a decrease in bone formation relative to
bone resorption, although the mechanisms for this impairment in bone formation with aging …

Aims: Emerging evidence suggests that the pathogenesis of osteoporosis, characterized by
impaired osteogenesis, is shifting from estrogen centric to oxidative stress. Our previous …

Fractures have an extraordinarily negative impact on individuals' quality of life and functional
status. Nonunion or disability of fracture is a major health issue with important clinical, social …