Chronic low back pain (cLBP) that cannot be attributable to a specific pathoanatomical
change is associated with high personal and societal costs. Still, the underlying mechanism …

Background DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-
fate decisions. Local deposition and removal of DNA methylation are tightly coupled with …

Bone regeneration is a promising avenue for osteoporosis (OP) treatment. It consists of
several procedures, such as the osteogenic differentiation of mesenchymal stem cells as …

Bone is a major organ in the skeletal system that supports and protects muscles and other
organs, facilitates movement and hematopoiesis, and forms a reservoir of minerals including …

Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …

Background Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by
diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone …

DNA methylation may be involved in the development of osteosarcomas. Osteosarcomas
commonly arise during the bone growth and remodeling in puberty, making it plausible to …

Background: Accumulating evidence suggests that postmenopausal osteoporosis (PMOP) is
a common chronic systemic metabolic bone disease, but its specific molecular pathogenesis …

Objective Osteoarthritis (OA) is polygenic with over 90 independent genome-wide
association loci so far reported. A key next step is the identification of target genes and the …

Epigenetic mechanisms including posttranslational histone modifications and DNA
methylation are emerging as important determinants of bone homeostasis. With our case …