Oocyte mitochondria are unique organelles that establish a founder population in primordial
germ cells (PGCs). As the oocyte matures in the postnatal mammalian ovary during …

Mitochondrial dysfunction may be acquired or inherited by oocytes without detectable
morphological abnormalities. This pathology may account for some examples of …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Oocyte mitochondria are increased in number, smaller, and rounder in appearance than
mitochondria in somatic cells. Moreover, mitochondrial numbers and activity are narrowly …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to
correct age-related oocyte aneuploidy caused by dysfunctional ooplasm. How healthy …

Background In human oocytes, as in other mammalian ova, there is a significant variation in
the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …