Capsules from Pathogenic and Non-Pathogenic Cryptococcus spp. Manifest Significant Differences in Structure and Ability to Protect against Phagocytic Cells

GS Araujo, FL Fonseca, B Pontes, A Torres… - PloS one, 2012 - journals.plos.org
Capsule production is common among bacterial species, but relatively rare in eukaryotic
microorganisms. Members of the fungal Cryptococcus genus are known to produce …

Molecular architecture of the Cryptococcus neoformans capsule

MA Gates, P Thorkildson, TR Kozel - Molecular microbiology, 2004 - Wiley Online Library
Many microbes are surrounded by phagocytosis‐inhibiting capsules. We took advantage of
the large size of the polysaccharide capsule of the pathogenic yeast Cryptococcus …

The Cryptococcus wall: A different wall for a unique lifestyle

L Mukaremera - Plos Pathogens, 2023 - journals.plos.org
The life-threatening fungal pathogens Cryptococcus neoformans and Cryptococcus gattii are
differentiated from all other human fungal pathogens by the presence of a gelatinous …

Cryptococcus neoformans capsular polysaccharides form branched and complex filamentous networks viewed by high-resolution microscopy

GRS Araujo, GN Fontes, D Leão, GM Rocha… - Journal of structural …, 2016 - Elsevier
Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in
immunocompromised individuals. Its main virulence factor is an extracellular polysaccharide …

Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 gene

YC Chang, R Cherniak, TR Kozel… - Infection and …, 1997 - Am Soc Microbiol
The extracellular polysaccharide capsule of Cryptococcus neoformans is a well-recognized
virulence factor. Strain 602 is an acapsular clinical isolate of unknown serotype which has …

The capsule of Cryptococcus neoformans

A Casadevall, C Coelho, RJB Cordero, Q Dragotakes… - Virulence, 2019 - Taylor & Francis
The capsule of Cryptococcus neoformans is its dominant virulence factor and plays a key
role in the biology of this fungus. In this essay, we focus on the capsule as a cellular …

The environmental yeast Cryptococcus liquefaciens produces capsular and secreted polysaccharides with similar pathogenic properties to those of C. neoformans

GRS Araújo, GJC Freitas, FL Fonseca, PEC Leite… - Scientific reports, 2017 - nature.com
Invasive fungal infections, including cryptococcosis, are a growing threat to
immunocompromised patients. Although Cryptococcus neoformans and Cryptococcus gattii …

Cryptococcus neoformans capsule regrowth experiments reveal dynamics of enlargement and architecture

MP Wear, E Jacobs, S Wang, SA McConnell… - Journal of Biological …, 2022 - ASBMB
The polysaccharide capsule of fungal pathogen Cryptococcus neoformans is a critical
virulence factor that has historically evaded complete characterization. Cryptococcal …

Extracellular Vesicles Produced by Cryptococcus neoformans Contain Protein Components Associated with Virulence

ML Rodrigues, ES Nakayasu, DL Oliveira… - Eukaryotic …, 2008 - Am Soc Microbiol
Cryptococcus neoformans produces vesicles containing its major virulence factor, the
capsular polysaccharide glucuronoxylomannan (GXM). These vesicles cross the cell wall to …

A Yeast under Cover: the Capsule of Cryptococcus neoformans

I Bose, AJ Reese, JJ Ory, G Janbon, TL Doering - Eukaryotic cell, 2003 - Am Soc Microbiol
Few fungi are pathogenic to humans. Of these, Cryptococcus neoformans has emerged as
an important cause of mortality in immunocompromised patients, especially those with AIDS …