FOXP2-related speech and language disorder (FOXP2-SLD) is caused by heterozygous
FOXP2 pathogenic variants (including whole-or partial-gene deletions). The core phenotype …

Aim To delineate the speech and language phenotype of a cohort of individuals with FOXP1‐
related disorder. Method We administered a standardized test battery to examine speech …

Relatively little is known about the neurobiological basis of speech disorders although
genetic determinants are increasingly recognized. The first gene for primary speech disorder …

Background Heterozygous disruptions of FOXP2 were the first identified molecular cause for
severe speech disorder: childhood apraxia of speech (CAS), and yet few cases have been …

Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …

Disruptions in FOXP2, a transcription factor, are the only known monogenic cause of speech
and language impairment. We report on clinical findings for two new individuals with a …

Abstract Mental retardation affects 2‐3% of the population and shows a high heritability.
Neurodevelopmental disorders that include pronounced impairment in language and …

Background Disruptions of the FOXP2 gene, encoding a forkhead transcription factor, are
the first known monogenic cause of a speech and language disorder. So far, mainly …

FOXP2, the first gene to have been implicated in a developmental communication disorder,
offers a unique entry point into neuromolecular mechanisms influencing human speech and …

The closely related paralogues FOXP2 and FOXP1 encode transcription factors with shared
functions in the development of many tissues, including the brain. However, while mutations …