Organoid systems to study the human female reproductive tract and pregnancy

L Alzamil, K Nikolakopoulou, MY Turco - Cell Death & Differentiation, 2021 - nature.com
Both the proper functioning of the female reproductive tract (FRT) and normal placental
development are essential for women's health, wellbeing, and pregnancy outcome. The …

Organoids of the female reproductive tract

C Chumduri, MY Turco - Journal of molecular medicine, 2021 - Springer
Healthy functioning of the female reproductive tract (FRT) depends on balanced and
dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The …

Organoid technology in female reproductive biomedicine

H Heidari-Khoei, F Esfandiari, MA Hajari… - Reproductive Biology …, 2020 - Springer
Recent developments in organoid technology are revolutionizing our knowledge about the
biology, physiology, and function of various organs. Female reproductive biology and …

Organoids to model the endometrium: implantation and beyond

TM Rawlings, K Makwana, M Tryfonos… - Reproduction and …, 2021 - raf.bioscientifica.com
Despite advances in assisted reproductive techniques in the 4 decades since the first
human birth after in vitro fertilisation, 1–2% of couples experience recurrent implantation …

Investigation of infertility using endometrial organoids

K Nikolakopoulou, MY Turco - Reproduction, 2021 - rep.bioscientifica.com
Infertility is a common problem in modern societies with significant socio-psychological
implications for women. Therapeutic interventions are often needed which, depending on …

Human-derived model systems in gynecological cancer research

K Lõhmussaar, M Boretto, H Clevers - Trends in cancer, 2020 - cell.com
The human female reproductive tract (FRT) is a complex system that combines series of
organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which …

Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability

M Boretto, B Cox, M Noben, N Hendriks… - …, 2017 - journals.biologists.com
The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic
tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily …

Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube

Y Xie, ES Park, D Xiang, Z Li - Stem cell research, 2018 - Elsevier
A recent paradigm shift in ovarian cancer research is the finding that many ovarian cancers
may originate from fallopian tube epithelial (FTE) cells. As tissue stem and progenitor cells …

Strategies for modelling endometrial diseases

AR Murphy, H Campo, JJ Kim - Nature Reviews Endocrinology, 2022 - nature.com
Each month during a woman's reproductive years, the endometrium undergoes vast
changes to prepare for a potential pregnancy. Diseases of the endometrium arise for …

Modeling human trophoblast, the placental epithelium at the maternal fetal interface

M Horii, O Touma, T Bui, MM Parast - Reproduction, 2020 - rep.bioscientifica.com
Appropriate human trophoblast lineage specification and differentiation is crucial for the
establishment of normal placentation and maintenance of pregnancy. However, due to the …