Aims Sepsis-induced acute kidney injury (SI-AKI) is the fifth most common cause of hospital-
acquired acute kidney injury. Pannexin1 (Panx1) triggers inflammation and apoptosis which …

Abstract Ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) in
clinic. The activation of NLRP3 inflammasome is associated with inflammation and renal …

Renal ischemia/reperfusion injury (IRI) is a significant challenge in perioperative medicine
and is related to oxidative programmed cell death. However, the role of ferroptosis, a newly …

Sepsis-induced acute kidney injury (AKI) represents a major cause of mortality in intensive
care units. Sivelestat, a selective inhibitor of neutrophil elastase (NE), can attenuate sepsis …

Acute kidney injury (AKI), which is associated with high mortality rates, involves renal
inflammation related to the activation of innate immunity. The inflammatory response in AKI …

Sepsis-induced inflammatory damage is a crucial cause of acute kidney injury (AKI), and AKI
is an ecumenical fearful complication in approximately half of patients with sepsis …

Extracellular ATP is an important signaling molecule throughout the inflammatory cascade,
serving as a danger signal that causes activation of the inflammasome, enhancement of …

Netrin-1 regulates inflammation but the mechanism by which this occurs is unknown. Here
we explore the role of netrin-1 in regulating the production of the prostanoid metabolite …

Contrast-induced acute kidney injury (CI-AKI) is a main cause of hospital-acquired renal
failure. Nevertheless, limited measures have been shown to be effective for the treatment of …

Liensinine is mainly derived from alkaloids extracted and isolated from lotus seeds
(Nelumbo nucifera Gaertn). It possesses anti-inflammatory, and antioxidant, according to …