Alterations in the composition of the extracellular matrix (ECM) critically regulate the cellular
responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of …

Extracellular matrix (ECM) is known to provide signals controlling cell shape, migration,
proliferation, differentiation, morphogenesis, and survival. Recent data shows that some of …

Controlled proteolysis of extracellular matrix components releases bioactive fragments or
unmasks cryptic sites that play key roles in controlling various physio-pathological …

Numerous extracellular proteins and glycosaminoglycans (GAG s) undergo limited
enzymatic cleavage resulting in the release of fragments exerting biological activities, which …

Extracellular matrix (ECM) proteins confer biomechanical properties, maintain cell
phenotype and mediate tissue repair (via release of sequestered cytokines and proteases) …

The term “matrikines” was coined for designating peptides liberated by partial proteolysis of
extracellular matrix macromolecules, which are able to regulate cell activities. Among these …

The extracellular matrix is comprised of 1100 core-matrisome and matrisome-associated
proteins and of glycosaminoglycans. This structural scaffold contributes to the organization …

Repair of tissue after injury depends on the synthesis of a fibrous extracellular matrix to
replace lost or damaged tissue. Newly deposited extracellular matrix is then re-modeled …

Extracellular matrix (ECM) has been a central topic in aging research for several years. Cell–
matrix interactions extend the interest in this topic both for normal tissue homeostatic …

Background: Proteolytically released extracellular matrix (ECM) fragments, matricryptins, are
biologically active and play important roles in wound healing. Following myocardial …