Differentially altered molecular signature of visceral adipose tissue in HIV-1–associated lipodystrophy

JM Gallego-Escuredo, J Villarroya… - JAIDS Journal of …, 2013 - journals.lww.com
Objective: Lipodystrophy in HIV-1–infected antiretroviral-treated patients is often associated
with opposite alterations in adipose tissue depots as follows: lipoatrophy of subcutaneous …

HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV-1/HAART-associated lipodystrophy

M Giralt, P Domingo, JP Guallar… - Antiviral …, 2006 - journals.sagepub.com
Background The aetiopathogenic bases of HIV-1-/highly active antiretroviral treatment
(HAART)-associated lipodystrophy (HALS) are poorly known, but this syndrome indicates …

Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic …

V Jan, P Cervera, M Maachi, M Baudrimont… - Antiviral …, 2004 - journals.sagepub.com
Objective To achieve a better understand of the pathophysiology of HIV-related lipoatrophy,
we compared the mRNA expression of adipocytokines in fat samples from patients and …

Lipodystrophy in HIV 1-infected patients: lessons for obesity research

F Villarroya, P Domingo, M Giralt - International journal of obesity, 2007 - nature.com
Lipodystrophy is a common alteration in HIV 1-infected patients under anti-retroviral
treatment. This syndrome is usually associated with peripheral lipoatrophy, central adiposity …

HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy

J Villarroya, J Diaz-Delfin, D Hyink, P Domingo… - 2010 - journals.sagepub.com
Background Lipodystrophy in HIV type-1 (HIV-1)-infected patients is the consequence of
effects originating from antiretroviral treatment and HIV-1 infection. We have studied adipose …

Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in …

K Kannisto, J Sutinen, E Korsheninnikova, RM Fisher… - Aids, 2003 - journals.lww.com
Objective: To determine the expressions of multiple genes in the subcutaneous adipose
tissue of HIV-positive, highly active antiretroviral therapy (HAART)-treated patients with and …

Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy

JA Johnson, JB Albu, ES Engelson… - American Journal …, 2004 - journals.physiology.org
The lipodystrophy syndrome (adipose tissue redistribution and metabolic abnormalities)
observed with highly active antiretroviral therapy (HAART) during human immunodeficiency …

Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy

M Kratz, JQ Purnell, PA Breen… - The Journal of …, 2008 - academic.oup.com
Context: The expression of adipogenic genes in sc adipose tissue has been reported to be
lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is …

Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy

CM Shikuma, N Hu, C Milne, F Yost, C Waslien… - Aids, 2001 - journals.lww.com
Objective To determine whether the peripheral fat wasting (lipodystrophy), which is seen in
association with highly active antiretroviral therapy (HAART) that includes a nucleoside …

Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy

J Sutinen, AM Häkkinen, J Westerbacka… - Aids, 2002 - journals.lww.com
Objective: To determine liver fat content in patients with highly active antiretroviral therapy
(HAART)-associated lipodystrophy. Background: Lipodystrophy in several animal models is …