Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …

The occurrence of atrial fibrillation (AF) is associated with progressive changes in the
calcium handling system of atrial myocytes. Calcium cycling instability has been implicated …

Key points Cardiac alternans–periodic beat‐to‐beat alternations in contraction, action
potential (AP) morphology or cytosolic calcium transient (CaT) amplitude–is a high risk …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of the
arrhythmogenic substrate is incomplete. Alternans, the beat-to-beat alternation in the shape …

Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular
level alternans is observed as beat-to-beat alternations in contraction, action potential (AP) …

Key points Cardiac alternans refers to a beat‐to‐beat alternation in contraction, action
potential (AP) morphology and Ca2+ transient (CaT) amplitude, and represents a risk factor …

Beat-to-beat alternations in the amplitude of the cytosolic Ca2+ transient (Ca2+ alternans)
are thought to be the primary cause of cardiac alternans that can lead to cardiac arrhythmias …

Cardiac alternans, defined as beat-to-beat alternations in action potential duration, cytosolic
Ca transient (CaT) amplitude, and cardiac contraction is associated with atrial fibrillation …

The L-type Ca current (I Ca, L), essential for normal cardiac function, also regulates dynamic
action potential (AP) properties that promote ventricular fibrillation. Blocking I Ca, L can …

Aims Although cardiac alternans is a known predictor of lethal arrhythmias, its underlying
causes remain largely undefined in disease settings. The potential role of, and mechanisms …