In sickle cell disease (SCD), adhesion of sickle red blood cells (SSRBCs) and activated
leukocytes in inflamed venules affects blood rheology, causing vaso-occlusive …

In sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by
repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion …

Sickle red blood cells (SSRBCs) are adherent to the endothelium, activate leukocyte
adhesion, and are deficient in bioactive nitric oxide (NO) adducts such as S-nitrosothiols …

In sickle cell disease (SCD), treatment of recurrent vasoocclusive episodes, leading to pain
crises and organ damage, is still a therapeutic challenge. Vasoocclusion is caused primarily …

Patients with sickle cell disease (SCD) have ongoing hemolysis that promotes endothelial
injury, complement activation, inflammation, vaso-occlusion, ischemia-reperfusion …

While neutrophils are the main effectors of protective innate immune responses, they are
also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood …

Transgenic sickle mice expressing βS hemoglobin have activated vascular endothelium in
multiple organs that exhibits enhanced expression of NF-ĸB and adhesion molecules and …

Inhibition of leukocyte adhesion to the vascular endothelium represents a novel and
important approach for decreasing sickle cell disease (SCD) vaso-occlusion. Using a …

Adherent neutrophils on vascular endothelium positively contribute to cell-cell aggregation
and vaso-occlusion in sickle cell disease (SCD). In the present study, we demonstrated that …

Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role
in vaso-occlusive manifestations of sickle cell disease. Notably, polymorphonuclear …