Abstract Sickle Cell Disease (SCD) is a painful, lifelong hemoglobinopathy inherited as a
missense point mutation in the hemoglobin (Hb) beta‐globin gene. This disease has …

Nitric oxide (NO), a vasodilator contributes to the vaso-occlusive crisis associated with the
sickle cell disease (SCD). Vascular nitric oxide helps in vasodilation, controlled platelet …

Painful vaso-occlusive crisis (VOC) is the most common complication of sickle cell disease
(SCD). Increasing evidence suggests that vaso-occlusion is initiated by increased …

The phenomenon known as renal “ischemic preconditioning,” whereby an initial ischemic
insult induces resistance against subsequent kidney damage, has been well established in …

Abstract Background: Pain during Vaso-Occlusive Crisis (VOC) is a hallmark of sickle cell
disease (SCD) as deoxygenated (sickled) red blood cells (RBC) aggregate in the …

In sickle cell (SS) vaso-occlusion, the culminating event is blockage of blood vessels by
sickled red blood cells (SS RBCs). As shown in animal models, SS RBC-induced vaso …

Redox-dependent migration and proliferation of vascular smooth muscle cells (SMCs) are
central events in the development of vascular proliferative diseases; however, the …

Thromboinflammatory diseases result from the interactions of vascular endothelial cells,
inflammatory cells, and platelets with cellular adhesion molecules, plasma proteins, and …

In human and murine models of sickle cell disease (SCD), heme oxygenase-1 (HO-1) is
induced in the kidney, an organ commonly involved in SCD. The present study assessed the …

In addition to its mediation of vascular relaxation and neurotransmission, nitric oxide (NO)
potently modulates oxygen radical reactions and inflammatory signaling. This participation …