Knockdown of BMI1 is sensitive to Paclitaxel in cervical and endometrial cancer

Y Zhao, Y Lin, W Yang, J Chen, X Jin - 2023 - researchsquare.com
Background BMI1, a critical member of the Polycomb Repressor Complex 1, plays a key role
in regulating cell proliferation, differentiation, and senescence; however, abnormal …

Knockdown BMI1 expression inhibits proliferation and invasion in human bladder cancer T24 cells

W Liang, D Zhu, X Cui, J Su, H Liu, J Han… - Molecular and Cellular …, 2013 - Springer
B cell-specific moloney murine leukemia virus integration site 1 (BMI1) is a transcriptional
repressor of polycomb repressive complex 1, which is involved in the proliferation …

PTC209, a specific inhibitor of BMI1, promotes cell cycle arrest and apoptosis in cervical cancer cell lines

J Li, Z Vangundy, M Poi - Anticancer Research, 2020 - ar.iiarjournals.org
Background/Aim: Aberrant expression of the BMI1 oncogene has been prevalently found in
a variety of human cancers, including cervical cancer. Recent studies have shown that …

[HTML][HTML] Silencing Bmi1 expression suppresses cancer stemness and enhances chemosensitivity in endometrial cancer cells

M Kim, S Lee, WH Park, DH Suh, K Kim, YB Kim… - Biomedicine & …, 2018 - Elsevier
Background Bmi1, a polycomb group gene, is essential for self-renewal of stem cells and is
frequently upregulated in various cancer cells. We aimed to investigate the effect of Bmi1 …

Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer

E Wang, S Bhattacharyya, A Szabolcs… - PloS one, 2011 - journals.plos.org
Undoubtedly ovarian cancer is a vexing, incurable disease for patients with recurrent cancer
and therapeutic options are limited. Although the polycomb group gene, Bmi-1 that regulates …

Overexpression of Bmi-1 in uterine cervical cancer: correlation with clinicopathology and prognosis

X Zhang, CX Wang, C Zhu, J Zhang, S Kan… - International Journal of …, 2010 - ijgc.bmj.com
Introduction: B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is a
member of polycomb group, which participates in axial patterning, hematopoiesis, cell cycle …

Overexpression of BMI‐1 is associated with poor prognosis in cervical cancer

YQ Tong, B Liu, HY Zheng, YJ He… - Asia‐Pacific Journal …, 2012 - Wiley Online Library
Aim It has been reported that BMI‐1, a gene transcription promoter overexpressed in various
human cancers, is associated with poor survival. We investigated whether BMI‐1 is a marker …

Role of BMI1 in epithelial ovarian cancer: investigated via the CRISPR/Cas9 system and RNA sequencing

Q Zhao, Q Qian, D Cao, J Yang, T Gui… - Journal of Ovarian …, 2018 - Springer
Background B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) might be
an appropriate biomarker in the management of epithelial ovarian cancer (EOC). However …

Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain

AK Yadav, AA Sahasrabuddhe, M Dimri, PV Bommi… - Molecular cancer, 2010 - Springer
Abstract Background The polycomb group (PcG) protein BMI1 is an important regulator of
development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell …

[PDF][PDF] Over-expression of BMI1 is associated with favorable prognosis in cervical cancer

BW Kim, H Cho, K Ylaya, JY Chung, SM Hewitt, JH Kim - 2016 - researchgate.net
Objective: B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), is a
Plycomb group (PCG) protein, that is involved in the epithelial-mesenchymal transition …