[HTML][HTML] Mesoporous silica coated spicules for photodynamic therapy of metastatic melanoma

X Liang, J Zhang, C Zhang, H Zhai, P Yang… - Journal of …, 2024 - Springer
We report on the fabrication of mesoporous silicon dioxide coated Haliclona sp. spicules
(mSHS) to enhance the delivery of the insoluble photosensitizer protoporphyrin IX (PpIX) …

In vitro studies of functionalized mesoporous silica nanoparticles for photodynamic therapy

HL Tu, YS Lin, HY Lin, Y Hung, LW Lo, YF Chen… - Advanced …, 2009 - hub.tmu.edu.tw
A simple surface modification process that conjugates a photosensitizer, photoporphyrin IX
(PpIX), with mesoporous silica nanoparticles (MSNs) through covalent bonding to yield PpIX …

Stimuli-responsive protoporphyrin IX silica-based nanoparticles for photodynamic therapy in vitro

JL Vivero-Escoto, DL Vega - Rsc Advances, 2014 - pubs.rsc.org
Nanoparticle-based delivery systems have been explored recently as efficient vehicles to
transport photosensitizers for photodynamic therapy (PDT). In this study; we report the …

[HTML][HTML] Verteporfin-loaded mesoporous silica nanoparticles' topical applications inhibit mouse melanoma lymphangiogenesis and micrometastasis in vivo

N Clemente, I Miletto, E Gianotti, M Sabbatini… - International Journal of …, 2021 - mdpi.com
Photodynamic therapy (PDT) has been pointed out as a candidate for improving melanoma
treatment. Nanotechnology application in PDT has increased its efficacy by reducing side …

Colloidal mesoporous silica nanoparticles with protoporphyrin IX encapsulated for photodynamic therapy

J Qian, A Gharibi, S He - Journal of biomedical optics, 2009 - spiedigitallibrary.org
Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized,
characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is …

[HTML][HTML] Verteporfin based silica nanoparticle for in vitro selective inhibition of human highly invasive melanoma cell proliferation

M Rizzi, S Tonello, BM Estevão, E Gianotti… - … of Photochemistry and …, 2017 - Elsevier
Photodinamic therapy (PDT) has gained an increasing interest as a new tool to treat skin
cancers such as melanoma. This clinical approach take advantage from the combination of …

Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer

IT Teng, YJ Chang, LS Wang, HY Lu, LC Wu, CM Yang… - Biomaterials, 2013 - Elsevier
This paper describes the fabrication of a highly efficient, non-cytotoxic drug delivery platform
designed for photodynamic therapy (PDT): phospholipid-capped, protoporphyrin IX–loaded …

Microneedle-assisted topical delivery of photodynamically active mesoporous formulation for combination therapy of deep-seated melanoma

HP Tham, K Xu, WQ Lim, H Chen, M Zheng… - ACS …, 2018 - ACS Publications
Topical treatment using photodynamic therapy (PDT) for many types of skin cancers has
largely been limited by the inability of existing photosensitizers to penetrate into the deep …

[HTML][HTML] Verteporfin-loaded mesoporous silica nanoparticles inhibit mouse melanoma proliferation in vitro and in vivo

N Clemente, I Miletto, E Gianotti, M Invernizzi… - … of Photochemistry and …, 2019 - Elsevier
Melanoma is one of the most lethal tumors among the skin cancers, arising from complex
genetic mutations in melanocyte. Melanoma microenvironment is very heterogeneous …

Spherical and rod shaped mesoporous silica nanoparticles for cancer-targeted and photosensitizer delivery in photodynamic therapy

W Borzęcka, PMR Pereira, R Fernandes… - Journal of Materials …, 2022 - pubs.rsc.org
Mesoporous silica nanoparticles (MSNPs) have attracted much attention in many biomedical
applications. One of the fields in which smart functional nanosystems have found wide …