Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung

M Hogardt, J Heesemann - Between pathogenicity and commensalism, 2012 - Springer
Pseudomonas aeruginosa is the leading pathogen of chronic cystic fibrosis (CF) lung
infection. Life-long persistance of P. aeruginosa in the CF lung requires a sophisticated …

[HTML][HTML] Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs—A Review

AM Sousa, MO Pereira - Pathogens, 2014 - mdpi.com
Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung
disease. Its long persistence in CF airways is associated with sophisticated mechanisms of …

[HTML][HTML] Positive Signature-Tagged Mutagenesis in Pseudomonas aeruginosa: Tracking Patho-Adaptive Mutations Promoting Airways Chronic Infection

I Bianconi, A Milani, C Cigana, M Paroni… - PLoS …, 2011 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa can establish life-long chronic
infections in the airways of cystic fibrosis (CF) patients. Persistent lifestyle is established with …

Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung

M Hogardt, J Heesemann - International Journal of Medical Microbiology, 2010 - Elsevier
The long-term persistance of P. aeruginosa in the cystic fibrosis (CF) lung is characterized
by the selection of a variety of genotypes and phenotypes that typically descend from one …

[HTML][HTML] Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections

C Winstanley, S O'Brien, MA Brockhurst - Trends in microbiology, 2016 - cell.com
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Pseudomonas aeruginosa Microevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted Virulence

A Bragonzi, M Paroni, A Nonis, N Cramer… - American journal of …, 2009 - atsjournals.org
Rationale: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas
aeruginosa strains develop mutations leading to clonal expansion. This microevolution is …

Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions

A Schick, R Kassen - … of the National Academy of Sciences, 2018 - National Acad Sciences
Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs

J Klockgether, N Cramer, S Fischer… - American journal of …, 2018 - atsjournals.org
Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …

Dynamics of Adaptive Microevolution of Hypermutable Pseudomonas aeruginosa during Chronic Pulmonary Infection in Patients with Cystic Fibrosis

C Hoboth, R Hoffmann, A Eichner… - The Journal of …, 2009 - academic.oup.com
Background. In patients with cystic fibrosis (CF), the emergence of hypermutable
Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently …

[HTML][HTML] Cystic Fibrosis-Niche Adaptation of Pseudomonas aeruginosa Reduces Virulence in Multiple Infection Hosts

NI Lorè, C Cigana, I De Fino, C Riva, M Juhas… - PloS one, 2012 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa is able to thrive in diverse ecological
niches and to cause serious human infection. P. aeruginosa environmental strains are …