Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung
M Hogardt, J Heesemann - Between pathogenicity and commensalism, 2012 - Springer
Pseudomonas aeruginosa is the leading pathogen of chronic cystic fibrosis (CF) lung
infection. Life-long persistance of P. aeruginosa in the CF lung requires a sophisticated …
infection. Life-long persistance of P. aeruginosa in the CF lung requires a sophisticated …
Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung
M Hogardt, J Heesemann - International Journal of Medical Microbiology, 2010 - Elsevier
The long-term persistance of P. aeruginosa in the cystic fibrosis (CF) lung is characterized
by the selection of a variety of genotypes and phenotypes that typically descend from one …
by the selection of a variety of genotypes and phenotypes that typically descend from one …
Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs—A Review
AM Sousa, MO Pereira - Pathogens, 2014 - mdpi.com
Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung
disease. Its long persistence in CF airways is associated with sophisticated mechanisms of …
disease. Its long persistence in CF airways is associated with sophisticated mechanisms of …
Positive Signature-Tagged Mutagenesis in Pseudomonas aeruginosa: Tracking Patho-Adaptive Mutations Promoting Airways Chronic Infection
I Bianconi, A Milani, C Cigana, M Paroni… - PLoS …, 2011 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa can establish life-long chronic
infections in the airways of cystic fibrosis (CF) patients. Persistent lifestyle is established with …
infections in the airways of cystic fibrosis (CF) patients. Persistent lifestyle is established with …
Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …
Pseudomonas aeruginosa Microevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted Virulence
A Bragonzi, M Paroni, A Nonis, N Cramer… - American journal of …, 2009 - atsjournals.org
Rationale: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas
aeruginosa strains develop mutations leading to clonal expansion. This microevolution is …
aeruginosa strains develop mutations leading to clonal expansion. This microevolution is …
Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions
Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …
Dynamics of Adaptive Microevolution of Hypermutable Pseudomonas aeruginosa during Chronic Pulmonary Infection in Patients with Cystic Fibrosis
C Hoboth, R Hoffmann, A Eichner… - The Journal of …, 2009 - academic.oup.com
Background. In patients with cystic fibrosis (CF), the emergence of hypermutable
Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently …
Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently …
Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs
J Klockgether, N Cramer, S Fischer… - American journal of …, 2018 - atsjournals.org
Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …
Cystic Fibrosis-Niche Adaptation of Pseudomonas aeruginosa Reduces Virulence in Multiple Infection Hosts
The opportunistic pathogen Pseudomonas aeruginosa is able to thrive in diverse ecological
niches and to cause serious human infection. P. aeruginosa environmental strains are …
niches and to cause serious human infection. P. aeruginosa environmental strains are …