In Chapter 1, I expounded on the dsRNA-targeting probe scene that serves as the backdrop
for both Chapters 2 and 3. New analytical methods for double-stranded RNA (dsRNA) need …

Fluorescent indicator displacement (FID) assays are an advantageous approach to convert
receptors into optical sensors that can detect binding of various ligands. In particular, the …

RNAs are emerging as important biomarkers and therapeutic targets. The strategy of directly
targeting double-stranded RNA (dsRNA) by triplex-formation is relatively underexplored …

A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-
NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd …

With the increasing knowledge about the diverse roles of RNAs within cells, much attention
has been paid to the development of RNA-binding fluorescent probes for the study of RNA …

RNA targeted high-throughput assays that allow for rapid detection of high affinity binding
ligands are important in RNA recognition studies. A number for fluorescent dyes have been …

Fluorescent intercalator displacement (FID) is a convenient and practical tool for identifying
new nucleic acid-binding ligands. The success of FID is based on the fact that it can be …

Here we report on triplex-forming peptide nucleic acid (PNA) probes having thiazole orange
(TO) as a base surrogate for fluorogenic sensing of double stranded RNA (dsRNA) …

Fluorogenic probes that signal the presence of specific DNA or RNA sequences are key
enabling tools for molecular disease diagnosis and imaging studies. Usually, at least one …

One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino
acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also …