Although numerous biophysical tools have provided effective systems to study nucleic acids,
our current knowledge on how RNA structure complements its function is limited. Therefore …

The efficacy of fluorescent hybridization assays is often limited by the low signal-to-
background ratio of the probes that can be partially overcome by sophisticated signal …

Fluorescently labeled oligonucleotides are commonly employed as probes to detect specific
DNA or RNA sequences in homogeneous solution. Useful probes should experience strong …

Fluorescent labeling of biological RNA is complicated by the narrow range of nucleoside
triphosphates that can be used for biological synthesis (ie, transcription) as well as the …

With the growing interest in the understanding of the importance of RNAs in health and
disease, detection of RNAs in living cells is of high importance. Fluorogenic dyes that light …

A robust analysis and discovery platform for antibiotics targeting the bacterial rRNA A-site
has been developed by incorporating a new emissive U surrogate into the RNA and labeling …

Labeling of long RNA molecules in a site-specific yet generally applicable manner is integral
to many spectroscopic applications. Here we present a novel covalent labeling approach …

Asymmetrically localized RNA has been found in many cell types and organisms and
contributes to important developmental processes, such as mating type switching in yeast,[1] …

Cellular activities rely on the coordination among various biomolecules. Over the years,
proximity labeling methods have becoming more and more important and popular thanks to …