Styrene dyes are useful imaging probes and fluorescent sensors due to their strong
fluorogenic responses to environmental changes or binding macromolecules. Previously …

The sequence-specific fluorescence labeling of nucleic acids is a prerequisite for various
methods including single-molecule Förster resonance energy transfer (smFRET) for the …

Environmentally sensitive labels constitute a new, attractive tool for monitoring biomolecular
interactions. 3-Hydroxychromone derivatives are of particular interest because they undergo …

Since the discovery of the RNA functions modulating gene expression, functional RNA has
become an attractive drug target. Ligand− RNA interactions have been studied by covalent …

The rapid growth of research focusing on RNA, especially for RNA interference applications,
has created a need for a robust method that can accurately determine the concentration of …

RNA labeling is a key step in studying RNA localization, folding, and structural dynamics
using fluorescence based assays. Current methods of fluorophore attachment to long (> 100 …

Efficient fluorogenic hybridization probes combine high brightness and specificity of
fluorescence signaling with large turn-on of fluorescence. Herein, we present an approach …

In order to overcome the pH limitations of triplex-forming peptide nucleic acid (PNA) in
binding to double-stranded RNA (dsRNA), we have recently proposed a new design of …

The combination of thiazole orange and thiazole red as an internal energy transfer-based
fluorophore pair in oligonucleotides provides an outstanding analytical tool to follow …

Because of their stable orientations and their minimal interference with native DNA
interactions and folding, emissive isomorphic nucleoside analogues are versatile tools for …