Acetaminophen modulates the expression of steroidogenesis-associated genes and estradiol levels in human placental JEG-3 cells

KA Addo, N Palakodety, RC Fry - Toxicological Sciences, 2021 - academic.oup.com
Acetaminophen is the only medication recommended for pain and fever management during
pregnancy. However, studies have reported an association between in utero …

Intrauterine exposure to acetaminophen and adverse developmental outcomes: epidemiological findings and methodological issues

Z Liew, A Ernst - Current Environmental Health Reports, 2021 - Springer
Abstract Purpose of Review Acetaminophen (or paracetamol) is one of the most commonly
used medications during pregnancy. We reviewed recent epidemiological evidence …

Assessing the impact of in-utero exposures: potential effects of paracetamol on male reproductive development

KR Kilcoyne, RT Mitchell - Archives of Disease in Childhood, 2017 - adc.bmj.com
Human male reproductive disorders (cryptorchidism, hypospadias, testicular cancer and low
sperm counts) are common and some may be increasing in incidence worldwide. These …

Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol

JR Reel, AD Lawton, JC LAMB IV - Toxicological Sciences, 1992 - academic.oup.com
Acetaminophen (APAP) was evaluated for reproductive toxicity in Swiss CD-1 mice using a
continuous breeding protocol. APAP was administered in the diet at 0, 0.25, 0.5, and …

Intrauterine exposure to paracetamol and aniline impairs female reproductive development by reducing follicle reserves and fertility

JB Holm, S Mazaud-Guittot… - Toxicological …, 2016 - academic.oup.com
Studies report that fetal exposure to paracetamol/acetaminophen by maternal consumption
can interfere with male reproductive development. Moreover, recent biomonitoring data …

Maternal paracetamol intake during pregnancy—impacts on offspring reproductive development

R Tadokoro-Cuccaro, BG Fisher… - Frontiers in …, 2022 - frontiersin.org
Paracetamol (acetaminophen) is the preferred antipyretic/analgesic for pregnant women as
it is believed there are no adverse fetal effects at the recommended dose. However …

Intergenerational effects on fertility in male and female mice after chronic exposure to environmental doses of NSAIDs and 17α-ethinylestradiol mixtures

P Philibert, I Stévant, S Déjardin, M Girard… - Food and Chemical …, 2023 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) and 17α-ethinylestradiol (EE2) are
extensively used in human and veterinary medicine. Due to their partial removal by …

[HTML][HTML] Prenatal acetaminophen affects maternal immune and endocrine adaptation to pregnancy, induces placental damage, and impairs fetal development in mice

K Thiele, ME Solano, S Huber, RA Flavell… - The American journal of …, 2015 - Elsevier
Acetaminophen (APAP; ie, Paracetamol or Tylenol) is generally self-medicated to treat fever
or pain and recommended to pregnant women by their physicians. Recent epidemiological …

Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo

S Leverrier-Penna, RT Mitchell, E Becker… - Human …, 2018 - academic.oup.com
STUDY QUESTION Does ibuprofen use during the first trimester of pregnancy interfere with
the development of the human fetal ovary? SUMMARY ANSWER In human fetuses …

[HTML][HTML] Endocrine disruptors and the male reproductive system

JB Stukenborg, RT Mitchell, O Söder - Best Practice & Research Clinical …, 2021 - Elsevier
In recent years, there has been an increased incidence in several of the most common
reproductive disorders, including hypospadias and cryptorchidism in newborns, and …