Acetaminophen elicits anti-estrogenic but not estrogenic responses in the immature mouse

R Patel, RJ Rosengren - Toxicology letters, 2001 - Elsevier
Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic
activity in estrogen-receptor positive human breast cancer cells. However, there is limited in …

[HTML][HTML] Impact of perinatal exposure to acetaminophen on hepatocellular metabolic function in offspring

K Wu, C Guo, X Lu, X Wu, H Pan… - American journal of …, 2016 - ncbi.nlm.nih.gov
Acetaminophen (APAP), an over the counter (OTC) medication, is widely used in antipyretic
treatment. Although the risk of dose-dependent cytotoxicity has been known, the potential …

Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: A nationwide cohort study

EY Choi, HE Jeong, Y Noh, A Choi, DK Yon… - PLoS …, 2023 - journals.plos.org
Background Existing data on the use of nonsteroidal anti-inflammatory drugs (NSAIDs)
during late pregnancy is well established, providing assurance. However, the use of NSAIDs …

Is there a causal relation between maternal acetaminophen administration and ADHD?

A Saad, S Hegde, T Kechichian, P Gamble… - PLoS …, 2016 - journals.plos.org
Objective Recent epidemiological studies reported an association between maternal intake
of acetaminophen (APAP) and attention deficit hyperactivity disorder (ADHD) in their …

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non …

P Mian, JN Van Den Anker, K van Calsteren… - Clinical …, 2020 - Springer
Abstract Background and Objective Little is known about acetaminophen (paracetamol)
pharmacokinetics during pregnancy. The aim of this study was to develop a physiologically …

Review of endocrine disruptors on male and female reproductive systems

HH You, G Song - Comparative Biochemistry and Physiology Part C …, 2021 - Elsevier
Endocrine disruptors (EDs) interfere with different hormonal and metabolic processes and
disrupt the development of organs and tissues, as well as the reproductive system. In …

Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish (Danio rerio)

DP Moreira, YM Ribeiro, CS Ferreira… - Archives of …, 2023 - Springer
Acetaminophen (ACE; paracetamol) is one of the most widely used nonsteroidal anti-
inflammatory drugs worldwide and is often found in aquatic systems, where it can act on …

[HTML][HTML] Sex-specific neurobehavioral and prefrontal cortex gene expression alterations following developmental acetaminophen exposure in mice

BH Baker, EE Rafikian, PB Hamblin, MD Strait… - Neurobiology of …, 2023 - Elsevier
Abstract Acetaminophen (N-acetyl-p-aminophenol (APAP), also known as paracetamol) is
one of the most common medications used by the general population, including pregnant …

A review of the literature on the effects of acetaminophen on pregnancy outcome

AR Scialli, R Ang, J Breitmeyer, MA Royal - Reproductive toxicology, 2010 - Elsevier
Acetaminophen is commonly used during pregnancy. Experimental animal studies do not
suggest increased malformations after therapeutic use of single-ingredient acetaminophen …

Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring

K Karimi, T Keßler, K Thiele, K Ramisch, A Erhardt… - Journal of …, 2015 - Elsevier
Background & Aims During pregnancy, acetaminophen is one of the very few medications
recommended by physicians to treat fever or pain. Recent insights from epidemiological …