Superantigens are classically defined as antigens that induce hyperactivation of the immune
system. They are traditionally associated with non-specific activation of T-cells that induces …

Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

The antibody molecule possesses a number of so-called unconventional binding sites in the
variable domain that are expressed and function independently from the antigen-binding …

Superantigens are powerful microbial toxins that activate the immune system by binding to
class II major histocompatibility complex and T-cell receptor molecules. They cause a …

Superantibody technology represents a method to enhance the potency and utility of
monoclonal antibodies. The blueprint for superantibody technology is taken from rare …

Superantigens secreted by the bacterial pathogen Staphyloccocus aureus are extremely
potent toxins that overstimulate the host immune system by binding to the MHC class II and T …

Superantigens secreted by Staphylococcus aureus and Streptococcus pyogenes interact
with the T-cell receptor and major histocompatibility class II molecules on antigen-presenting …

Abstract Heinz Kohler and Sudhir Paul propose the term superantibody to describe
multifunctional antibodies that combine the classical antigen-binding function with a …

Staphylococcus aureus bacteria utilize an extensive array of molecular countermeasures to
manipulate the defensive microenvironment of the infected host and colonize potentially any …

The exotoxins produced by Staphylococcus aureus and Streptococcus pyogenes are
prototype molecules for the larger family of superantigens (SAGs). This family now includes …