Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome
Staphylococcal superantigens are pyrogenic exotoxins that cause massive T cell activation
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 Å resolution: implications for superantigen recognition by MHC class II molecules and T …
AC Papageorgiou, HS Tranter, KR Acharya - Journal of molecular biology, 1998 - Elsevier
Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …
B cell superantigens: a microbe's answer to innate-like B cells and natural antibodies
CS Goodyear, GJ Silverman - Springer seminars in immunopathology, 2005 - Springer
Marginal zone B cells and B-1 cells have been termed innate-like B cells as they express
limited repertoires that play special roles in immune defenses against common infections …
limited repertoires that play special roles in immune defenses against common infections …
[HTML][HTML] Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization
Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T
cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system …
cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system …
Broad-spectrum immunity against superantigens is elicited in mice protected from lethal shock by a superantigen antagonist peptide
G Arad, D Hillman, R Levy, R Kaempfer - Immunology letters, 2004 - Elsevier
Bypassing the restricted presentation of conventional antigens, superantigens trigger an
excessive cellular immune response leading to toxic shock. Antagonist peptides that inhibit …
excessive cellular immune response leading to toxic shock. Antagonist peptides that inhibit …
Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome
AY Tilahun, VR Chowdhary, CS David… - The Journal of …, 2014 - journals.aai.org
Life-threatening infections caused by Staphylococcus aureus, particularly the community-
acquired methicillin-resistant strains of S. aureus, continue to pose serious problems …
acquired methicillin-resistant strains of S. aureus, continue to pose serious problems …
[HTML][HTML] Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens
Staphylococcus aureus and group A Streptococcus secrete a collection of toxins called
superantigens (SAgs), so-called because they stimulate a large fraction of an individual's T …
superantigens (SAgs), so-called because they stimulate a large fraction of an individual's T …
Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.
M Dohlsten, G Hedlund, E Akerblom… - Proceedings of the …, 1991 - National Acad Sciences
The bacterial superantigen staphylococcal enterotoxin (SE) A (SEA) directs cytotoxic T
lymphocytes (CTLs) expressing particular sequences of the T-cell receptor (TCR) beta chain …
lymphocytes (CTLs) expressing particular sequences of the T-cell receptor (TCR) beta chain …
Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
The humanization of antibodies for therapeutics is a critical process that can determine the
success of antibody drug development. However, the science underpinning this process …
success of antibody drug development. However, the science underpinning this process …
Targeting of superantigens
T Kalland, M Dohlsten, L Abrahmsén, G Hedlund… - Cell biophysics, 1993 - Springer
The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent
activator of T lymphocytes when presented on MHC class II antigens. In order to induce T …
activator of T lymphocytes when presented on MHC class II antigens. In order to induce T …