The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying
pathology of migraine by promoting the development of a sensitized state of primary and …

The calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of several
pain-related syndromes, including migraine. Targeting CGRP and its receptor by their …

Migraine is a neurovascular syndrome associated with a unilateral, throbbing headache
accompanied by nausea, vomiting and photo/phonophobia. Several proteins are involved in …

Objective The objective of this study was to analyze the evolution of alpha and beta‐CGRP
circulating levels throughout CGRP monoclonal antibodies (mAbs) treatment in patients with …

More than 30 years ago Goadsby and Edvinsson revealed in their landmark experiments
that calcitonin gene-related peptide (CGRP) plays an essential role in trigeminal …

Over the last 100 years, the discovery of new analgesics has been a complex and difficult
task. However, remarkable progress in the identification of novel molecular targets relevant …

Cortical spreading depression (CSD) is believed to be a phenomenon underlying migraine
auras. The mutations of hemiplegic migraine genes are demonstrated to cause a reduction …

Background: There is ongoing debate about whether the oculomotor (III), trochlear (IV), or
abducens (VI) nerve paresis in patients with migraine is directly attributable to migraine …

Sumatriptan-induced changes in plasma calcitonin gene-related peptide (CGRP)
concentration and headache intensity were investigated in 19 female migraineurs during …

Introduction: Sensitisation of the nervous system in a patient with migraine is supposed to be
associated with calcitonin gene-related peptide (CGRP) activity. Therefore, the vascular …