Pharmacokinetics of hypertension medications is significantly affected by circadian rhythms
that influence absorption, distribution, metabolism and elimination. Furthermore, their …

ABSTRACT The pharmacokinetics (PK)–absorption, distribution, metabolism, and
elimination–and pharmacodynamics (PD) of hypertension medications can be significantly …

The pharmacodynamics of hypertension medications can be significantly affected by
circadian rhythms in the biological mechanisms of the 24 h blood pressure (BP) pattern …

Abstract Purpose of Review Current hypertension guidelines do not provide
recommendation on when-to-treat. Herein, we review the current evidence on ingestion-time …

Introduction Hypertension guidelines do not recommend the time to administer blood
pressure (BP)-lowering medications, despite multiple prospective clinical trials reporting …

Current hypertension guidelines fail to provide a recommendation on when-to-treat, thus
disregarding relevant circadian rhythms that regulate blood pressure (BP) level and 24 h …

The main purpose of this commentary is to update, based on our extensive review of the
published literature of the past 45 yrs, the differential therapeutic effects of hypertension …

Combined evidence of published prospective outcome trials and meta-analyses
substantiate elevated asleep blood pressure (BP) and blunted sleep-time relative BP …

Correlation between blood pressure (BP) target organ damage, cardiovascular risk, and
long-term prognosis is greater for ambulatory monitored (ABPM) than daytime in-clinic …

Clinical studies have documented morning-evening, administration-time differences of
several different classes of hypertension medications in blood pressure (BP)-lowering …