Acute kidney injury (AKI) represents a sudden reduction in renal function and is a major
clinical problem with a high mortality rate. Despite decades of research, there are currently …

The kidneys receive approximately 20% of cardiac output and have a low fractional oxygen
extraction. Quite paradoxically, however, the kidneys are highly susceptible to ischemic …

Ischaemia/reperfusion is a major cause of acute kidney injury in native and transplant
kidneys and is associated with significant morbidity and mortality. Murine models of renal …

Red blood cell (RBC) trapping is common in ischemic acute kidney injury (AKI) and presents
as densely packed RBCs that accumulate within and engorge the kidney medullary …

In this study, we compared the traditional murine model with renal pedicle clamp with
models that clamped the renal artery or vein alone as well as to a whole body ischemia …

Renal ischemia-reperfusion leads to acute kidney injury (AKI), a major kidney disease
associated with an increasing prevalence and high mortality rates. A variety of experimental …

Acute kidney injury is associated with alterations in vascular tone that contribute to an
overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations …

Severe acute kidney injury has a high mortality and is a risk factor for progressive chronic
kidney disease. None of the potential therapies that have been identified in preclinical …

Recent evidence suggests that injury to the renal vasculature may play an important role in
the pathogenesis of both early and chronic ischemic acute kidney injury (AKI). Established …

Acute kidney injury (AKI) remains one of the main causes of morbidity and mortality in the
intensive care medicine today. Its pathophysiology and progress to chronic kidney disease …