Simple Summary The dysregulation of UPS exacerbates the tumor microenvironment and
drives malignant transformation. As the largest family of E3 ligases, the SCFF-boxes …

The initiation and progression of breast cancer (BRCA) is associated with inflammation and
immune-overactivation, which is critically modulated by the E3 ubiquitin ligase. However, the …

SCF (Skp1/Cul1/F‐box) ubiquitin ligases act as master regulators of cellular homeostasis by
targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F‐box …

In cancer, many genes are mutated by genome rearrangement, but our understanding of the
functional consequences of this remains rudimentary. Here we report the F-box protein …

F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein)
E3 ligase complexes, play critical roles in the development and progression of human …

Introduction: F-box proteins are the substrate-recognizing subunits of SKP1 (S-phase kinase-
associated protein 1)–cullin1–F-box protein (SCF) E3 ligase complexes that play pivotal …

Abstract SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for
the degradation of proteins in a strictly regulated manner, through which it exerts pivotal …

The ubiquitin system controls protein stability and function. F-box proteins form SCF (SKP1-
Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively target their substrates for …

Casitas B-lineage lymphoma (CBL) is a ubiquitin ligase (E3) that becomes activated upon
Tyr371-phosphorylation and targets receptor protein tyrosine kinases for ubiquitin-mediated …

Fascin actin-bundling protein 1 (FSCN1), an actin-bundling protein associated with cell
migration and invasion, is highly expressed in various tumor tissues. FSCN1 has also been …